Fantofarone, SR-33557
泛托法隆Chemical Name: 2-Isopropyl-1-[4-[3-[N-methyl-N-[2-(3,4-dimethoxyphenyl)ethyl]amino]propoxy]phenylsulfonyl]indolizine
CAS No. 114432-13-2
项目整合开发状态: Phase III
项目研究机构: Labaz (Originator), Sanofi-Aventis (Originator)
合成路线:This compound has been obtained by two similar ways:1) The alkylation of 4-hydroxyphenyl(2-isopropylindolizin-1-yl)sulfone (I) 1,3-dibromopropane (II) by means of K2CO3 in DMF gives 4-(3-bromopropoxy)phenyl(2-isopropylindolizin-1-yl)sulfone (III),which is finally condensed with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.2) By direct condensation of sulfone (I) with the tertiary amine N-(3-chloropropyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.
📌 参考资料/链接：
参考文献标题:Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(Aminoalkoxy)phenyl]sulfonyl]indolizines
文献作者:Gubin,J.; de Vogelaer,H.; Inion,H.; Houben,C.; Lucchetti,J.; Mahaux,J.; Rosseels,G.; Peiren,M.; Clinet,M.; Polster,P.; et al.
参考来源:J Med Chem 1993,36(10),1425
📄 详细内容
合成路线:This compound has been obtained by two similar ways:1) The alkylation of 4-hydroxyphenyl(2-isopropylindolizin-1-yl)sulfone (I) 1,3-dibromopropane (II) by means of K2CO3 in DMF gives 4-(3-bromopropoxy)phenyl(2-isopropylindolizin-1-yl)sulfone (III),which is finally condensed with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.2) By direct condensation of sulfone (I) with the tertiary amine N-(3-chloropropyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.
参考文献标题:Aminoalkoxybenzenesulfonyl heterocyclic compounds,a novel class of calcium channel antagonists.Structure-activity relationship with a focus on fantofarone,SR 33557
文献作者:Chatelain,P.; Gubin,J.
参考来源:Drugs Fut 1993,18(9),817
合成路线:This compound has been obtained by two similar ways:1) The alkylation of 4-hydroxyphenyl(2-isopropylindolizin-1-yl)sulfone (I) 1,3-dibromopropane (II) by means of K2CO3 in DMF gives 4-(3-bromopropoxy)phenyl(2-isopropylindolizin-1-yl)sulfone (III),which is finally condensed with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.2) By direct condensation of sulfone (I) with the tertiary amine N-(3-chloropropyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.
参考文献标题:A novel class of calcium-entry blockers: The 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines
文献作者:Gubin,J.; Lucchetti,J.; Mahaux,J.; Nisato,D.; Rosseels,G.; Clinet,M.; Polster,P.; Chatelain,P.
参考来源:J Med Chem 1992,35(6),981
产品链接: CAS No. 114432-13-2››