Fasoracetam, NS-105, LAM-105
法索西坦 (5S)-5-(哌啶-1-羰基)吡咯里丁-2-1 5-(哌啶-1-羰基)吡咯烷-2-酮Chemical Name: (R)-1-[(5-Oxo-2-pyrrolidinyl)carbonyl]piperidine; (R)-5-(Piperidin-1-ylcarbonyl)pyrrolidin-2-one
CAS No. 110958-19-5, 110958-23-1 ((S)-isomer), 59388-44-2 (undefined isomer)
项目整合开发状态: Phase III
项目研究机构: Nippon Shinyaku (Originator)
合成路线:By condensation of D-pyroglutamic acid (I) with piperidine (II) by means of dicyclohexylcarbodiimide (DCC) in acetonitrile.
📌 参考资料/链接：
参考文献标题:Pyroglutamide derivs
文献作者:Kimura,K.; Chokai,S.; Tomita,T.; Kise,M.; Nakamura,K.(Nippon Shinyaku Co.,Ltd.)
参考来源:DE 3701494; FR 2597100; GB 2185483; JP 1987252761; JP 1987252762; JP 1988146857; US 5102882
📄 详细内容
合成路线:By condensation of D-pyroglutamic acid (I) with piperidine (II) by means of dicyclohexylcarbodiimide (DCC) in acetonitrile.
参考文献标题:Synthesis and learning and memory enhancing action of a new pyroglutamic acid amide derivative
文献作者:Joseki,S.; Nakamura,K.; Tomita,T.; Oshe,M.; Sugiyama,S.; Ogasawara,T.; Kimura,K.
参考来源:108th Annu Meet Pharm Soc Jpn (April 4-7,Hiroshima) 1988,Abst 4 E11 3-1
合成路线:By condensation of D-pyroglutamic acid (I) with piperidine (II) by means of dicyclohexylcarbodiimide (DCC) in acetonitrile.
参考文献标题:NS-105
文献作者:Graul,A.; Tracy,M.; Castar,J.
参考来源:Drugs Fut 1997,22(6),639