Falipamil, AQ-A-39
法利帕米Chemical Name: 5,6-Dimethoxy-2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]phthalamidine; 2-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-2,3-dihydro-5,6-dimethoxy-1H-isoindol-1-one
CAS No. 77862-92-1, 60987-07-7 (monoHCl)
项目整合开发状态: Phase II
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The condensation of 4,5-dimethoxyphthalic anhydride (I) with 3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propylamine (II) in refluxing acetic acid gives 5,6-dimethoxy-2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propylphthalamide (III),which is reduced with Zn in refluxing acetic acid.
📌 参考资料/链接：
参考文献标题:AQ-A-39
文献作者:Castar,J.; Koch,H.
参考来源:Drugs Fut 1981,6(7),402
📄 详细内容
合成路线:The condensation of 4,5-dimethoxyphthalic anhydride (I) with 3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propylamine (II) in refluxing acetic acid gives 5,6-dimethoxy-2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propylphthalamide (III),which is reduced with Zn in refluxing acetic acid.
参考文献标题:
文献作者:Eberlein,W.; et al.
参考来源:US 4038407
产品链接: CAS No. 77862-92-1›› 产品链接: CAS No.60987-07-7››