合成路线:a) N-Protected L-Leucine activated as the pentafluorophenyl ester (I) is coupled with L-prolinamide (II),and the resulting dipeptide (III) is deprotected te (IV) and coupled with L-pyro-2-aminoadipic acid pentatluorophenyl ester (V) to give RGH-2202.
合成路线:b) Large scale preparation of L-pyro-2-aminoadipic acid (IX) is accomplished by oxidation of the N-protected L-lysine derivative (VI) with KMnO4 followed by deprotection to (VIII) and cyclization.
参考文献标题:Synthesis of thyrotropin releasing hormone analogu
文献作者:Szirtes,T.; Kisfaludy,L.; P醠osi,?; Szporny,L.
参考来源:J Med Chem 1984,27741
合成路线:a) N-Protected L-Leucine activated as the pentafluorophenyl ester (I) is coupled with L-prolinamide (II),and the resulting dipeptide (III) is deprotected te (IV) and coupled with L-pyro-2-aminoadipic acid pentatluorophenyl ester (V) to give RGH-2202.
合成路线:b) Large scale preparation of L-pyro-2-aminoadipic acid (IX) is accomplished by oxidation of the N-protected L-lysine derivative (VI) with KMnO4 followed by deprotection to (VIII) and cyclization.
参考文献标题:Synthesis of thyrotropin-releasing hormone analogu
文献作者:Szirtes,T.; Kisfaludy,L.; P醠osi,?; Szporny,L.
参考来源:J Med Chem 1986,291654
产品链接: CAS No. 78664-73-0››