Clobenoside, ZY-15028, Floganol, Arvigol
氯苄葡甙Chemical Name: Ethyl 5,6-bis-O-(4-chlorobenzyl)-3-O-propyl-D-glucofuranoside; Ethyl 5,6-bis-O-[(4-chlorophenyl)methyl]-3-O-propyl-D-glucofuranoside
CAS No. 29899-95-4
项目整合开发状态: Launched-1988
项目研究机构: Gebro Pharma (Originator), Vifor (Licensee)
合成路线:The reaction of 1,2-O-isopropylidene-3-O-propyl-alpha-D-glucofuranose (I) with 4-chlorobenzyl chloride (II) by means of KOH in hot dioxane gives 1',2-O-iso-propylidene-3-O-propyl-5,6-di-O-(4-chlorobenzyl)-alpha-D-glucofuranose (III),which is then hydrolyzed with ethanolic HCl.
📌 参考资料/链接：
参考文献标题:Anti-inflammatory glucose derivatives
文献作者:Iselin,B.; Rossi,A.; Kessler,W.; Walter,A.(Novartis Corp.)
参考来源:BE 0720622; DE 1793338; FR 1588563; GB 1246117; US 3655884
📄 详细内容
合成路线:The reaction of 1,2-O-isopropylidene-3-O-propyl-alpha-D-glucofuranose (I) with 4-chlorobenzyl chloride (II) by means of KOH in hot dioxane gives 1',2-O-iso-propylidene-3-O-propyl-5,6-di-O-(4-chlorobenzyl)-alpha-D-glucofuranose (III),which is then hydrolyzed with ethanolic HCl.
参考文献标题:Clobenoside
文献作者:Castar,J.; Koch,H.; Serradell,M.N.
参考来源:Drugs Fut 1985,10(12),977
产品链接: CAS No. 29899-95-4››