Lotifazole, F-1686
氯替法唑Chemical Name: N-(4-Phenylthiazol-2-yl)carbamic acid 2,2,2-trichloroethyl ester
CAS No. 71119-10-3
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The cyclization of acetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-phenyl-2-aminothiazole (III),which is then condensed with 2,2,2-trichloroethyl chloroformate (IV) by means of NaHCO3 in acetone.
📌 参考资料/链接：
参考文献标题:
文献作者:
参考来源:EP 1727; FR 2406634; JP 7961172
📄 详细内容
合成路线:The cyclization of acetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-phenyl-2-aminothiazole (III),which is then condensed with 2,2,2-trichloroethyl chloroformate (IV) by means of NaHCO3 in acetone.
参考文献标题:Lotifazole
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1981,6(10),624
产品链接: CAS No. 71119-10-3››