Cloranolol hydrochloride, GYKI-41099, Tobanum
氯拉洛尔Chemical Name: 1-(2,5-Dichlorophenoxy)-3-(tert-butylamino)-2-propanol hydrochloride
CAS No. 39563-28-5
项目整合开发状态: Launched-1981
项目研究机构: Gedeon Richter (Originator)
合成路线:Compound can be prepared in three different ways:1) Condensation of 2,5-dichlorophenol (I) with epichlorohydrin (A) by means of NaOH in water to give 1-(2,5-dichlorophenoxy)-2,3-epoxypropane (II),which is then condensed again with tert-butylamine in refluxing ethanol.Finally,HCl in ethanol is added.2) Condensation of (I) with epichlorohydrin (A) by means of pyridine gives 1-(2,5-dichlorophenoxy)-3-chloro-2-propanol (III),which is then condensed with tert-butylamine as before.3) Condensation of (I) with 1-(tertbutylamino)-2,3-epoxypropane (B) or with 1-(tertbutylamino)-3-chloro-2-propanol (C) by means of NaOH in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:GYKI-41099
文献作者:Castar,J.; Sumgurbey,K.
参考来源:Drugs Fut 1978,3(4),295
📄 详细内容
合成路线:Compound can be prepared in three different ways:1) Condensation of 2,5-dichlorophenol (I) with epichlorohydrin (A) by means of NaOH in water to give 1-(2,5-dichlorophenoxy)-2,3-epoxypropane (II),which is then condensed again with tert-butylamine in refluxing ethanol.Finally,HCl in ethanol is added.2) Condensation of (I) with epichlorohydrin (A) by means of pyridine gives 1-(2,5-dichlorophenoxy)-3-chloro-2-propanol (III),which is then condensed with tert-butylamine as before.3) Condensation of (I) with 1-(tertbutylamino)-2,3-epoxypropane (B) or with 1-(tertbutylamino)-3-chloro-2-propanol (C) by means of NaOH in refluxing ethanol.
参考文献标题:Aminopropanol derivative
文献作者:Hajos,A.; et al.
参考来源:DE 2213044; FR 2130284; GB 1337921; NL 7203323
产品链接: CAS No. 39563-28-5››