合成路线:The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III),which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV).Finally,this compound is treated with dipentylamine (V) in water.
参考文献标题:Lorglumide
文献作者:Castar,J.; Serradell,M.N.; Castar,R.M.
参考来源:Drugs Fut 1987,12(9),851
合成路线:The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III),which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV).Finally,this compound is treated with dipentylamine (V) in water.
参考文献标题:Differentiation of central and peripheral cholecystokinin receptors by new glutaramic acid derivatives with cholecystokinin-antagonistic activity
文献作者:Rovati,L.C.; Chiste,R.; Bani,M.; Revel,L.; Makovec,F.; Rovati,L.A.
参考来源:Arzneim-Forsch Drug Res 1986,36(1),98-102
合成路线:The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III),which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV).Finally,this compound is treated with dipentylamine (V) in water.
参考文献标题:New glutaramic acid derivatives with potent competitive and specific cholecystokinin-antagonistic activity
文献作者:Chiste,R.; Makovec,F.; Rovati,L.A.; Pacini,M.A.; Bani,M.; Setnikar,I.
参考来源:Arzneim-Forsch Drug Res 1985,35(7),1048-1051
合成路线:The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III),which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV).Finally,this compound is treated with dipentylamine (V) in water.
参考文献标题:
文献作者:Zrenner,E.; Laties,A.M.
参考来源:Eur J Med Chem - Chim Ther 1986,21(1),9-20
产品链接: CAS No. 97964-56-2››