合成路线:The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III),which is treated first with sodium and then with chlorine to give the compound (IV).This compound is finally hydrolyzed with refluxing concentrated HCl,or treated with refluxing tetrachloroethane.
参考文献标题:Clodronate disodium
文献作者:Castar,J.; Hopkins,S.J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(9),615
合成路线:The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III),which is treated first with sodium and then with chlorine to give the compound (IV).This compound is finally hydrolyzed with refluxing concentrated HCl,or treated with refluxing tetrachloroethane.
参考文献标题:Substituted methylene diphosphonic acids and their salts
文献作者:Roy,C.H.
参考来源:NL 6514133
合成路线:The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III),which is treated first with sodium and then with chlorine to give the compound (IV).This compound is finally hydrolyzed with refluxing concentrated HCl,or treated with refluxing tetrachloroethane.
参考文献标题:Tetrasodium carbonyldiphosphonate.Synthesis reactions and spectral properties
文献作者:Nicholson,D.A.; Prentice,J.B.; Quimby,O.T.
参考来源:J Org Chem 1967,32(12),4111-14
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