Diclondazolic acid, Lonidamine, KN-228, AF-1890, Doridamina
氯尼达明Chemical Name: 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid
CAS No. 50264-69-2
项目整合开发状态: Launched-1987
项目研究机构: Angelini (Originator), Kanebo (Licensee), Nippon Shinyaku (Licensee)
合成路线:By condensation of 1H-indazole-3-carboxylic acid (I) with 2,4-dichlorobenzyl chloride (II) by means of NaOH in water heated over a steam bath.
合成路线:The alkylation of ethyl 1H-indazole-3-carboxylate (I) with 4-chloro-2-methylbenzyl chloride (II) by means of sodium ethoxide in refluxing ethanol gives ethyl 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylate (III),which is then hydrolyzed with NaOH in refluxing ethanol - water.
📌 参考资料/链接：
参考文献标题:Substituted 1-benzyl-1H-indazole-3-carboxylic acids and derivatives thereof
文献作者:Palazzo,G.; Silvestrini,B.(ACRAF SpA)
参考来源:DE 2310031; FR 2181773; GB 1381422; US 3895026
📄 详细内容
合成路线:By condensation of 1H-indazole-3-carboxylic acid (I) with 2,4-dichlorobenzyl chloride (II) by means of NaOH in water heated over a steam bath.
参考文献标题:Lonidamine
文献作者:Hillier,K.
参考来源:Drugs Fut 1979,4(4),265
合成路线:By condensation of 1H-indazole-3-carboxylic acid (I) with 2,4-dichlorobenzyl chloride (II) by means of NaOH in water heated over a steam bath.
合成路线:The alkylation of ethyl 1H-indazole-3-carboxylate (I) with 4-chloro-2-methylbenzyl chloride (II) by means of sodium ethoxide in refluxing ethanol gives ethyl 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylate (III),which is then hydrolyzed with NaOH in refluxing ethanol - water.
参考文献标题:1-Halobenzyl-1H-3-carboxylic acids.A new class of antispermatogenic agents
文献作者:Corsi,G.; Palazzo,G.
参考来源:J Med Chem 1976,19(6),778-783
产品链接: CAS No. 50264-69-2››