(R)-Oxaprotiline hydrochloride, Levoprotiline hydrochloride, CGP-12103A
左丙替林 Chemical Name: (-)-1-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)-3-(methylamino)propan-2(R)-ol
CAS No. 76496-69-0, 76496-68-9 (free base)
项目整合开发状态: Pre-Registered
项目研究机构: Novartis (Originator)
合成路线:Levoprotiline (II) is the levorotatory R-enantiomer of oxaprotitine (I).It is obtained by resolution of oxaprotitine via its (-)-di-O,O'-p-toluoyl-L-tartaric acid salt,which is then cleaved with hydrogen chloride to levoprotiline hydrochloride (CGP-12 103 A).By an analogous procedure,using (+)-di-O,O'-p-toluoyl-D-tartaric acid,the dextrarotatory S-enantiomer,CGP 12 104 A (III),is gained from oxaprotiline.
📌 参考资料/链接：
参考文献标题:Novel levorotatory basic deriv.of 9,10-ethaneant
文献作者:Storni,A.(Novartis AG)
参考来源:EP 0014433; JP 1991271263; US 5004755
📄 详细内容
合成路线:Levoprotiline (II) is the levorotatory R-enantiomer of oxaprotitine (I).It is obtained by resolution of oxaprotitine via its (-)-di-O,O'-p-toluoyl-L-tartaric acid salt,which is then cleaved with hydrogen chloride to levoprotiline hydrochloride (CGP-12 103 A).By an analogous procedure,using (+)-di-O,O'-p-toluoyl-D-tartaric acid,the dextrarotatory S-enantiomer,CGP 12 104 A (III),is gained from oxaprotiline.
参考文献标题:Levoprotiline hydrochloride
文献作者:Hauser,K.; Storni,A.; Maitre,L.
参考来源:Drugs Fut 1988,13(11),956
产品链接: CAS No. 76496-69-0›› 产品链接: CAS No.76496-68-9››