Nicafenine
尼卡非宁Chemical Name: 2-(7-Chloroquinolin-4-ylamino)benzoic acid 2-(pyridin-3-ylcarboxamido)ethyl ester
CAS No. 64039-88-9
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The esterification of 2-carboxyphenylcarbamic acid anhydride (I) with N-(2-hydroxyethyl)nicotinamide (II) by means of NaOH in hot dioxane gives the corresponding ester of anthranilic acid (III),which is then condensed with 4,7-dichloroquinoline (IV) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:
文献作者:Cousse,H.; Mouzin,G.
参考来源:BE 849004; CH 608804; DE 2656852; FR 2335223; NL 7613605; US 4122181; US 4152521
📄 详细内容
合成路线:The esterification of 2-carboxyphenylcarbamic acid anhydride (I) with N-(2-hydroxyethyl)nicotinamide (II) by means of NaOH in hot dioxane gives the corresponding ester of anthranilic acid (III),which is then condensed with 4,7-dichloroquinoline (IV) in refluxing ethanol.
参考文献标题:Nicafenine
文献作者:Aboul-Enein,H.Y.
参考来源:Drugs Fut 1980,5(7),357
产品链接: CAS No. 64039-88-9››