合成路线:This compound can be obtained by two different ways:1) By fluorination of 8,9-anhydroerythromycin A 6,9-hemiketal N-oxide (I) with trifluoromethyl hypofluorite (or perchloryl fluoride),followed by reduction of the corresponding N-oxide obtained.2) By biological synthesis,starting from (8S)-8-fluoroerythronolide A (II) in a culture broth of Streptomyces erythraeus ATCC 31772,a blocked mutant of an erythromycin-producing strain.
参考文献标题:Enzyme inhibitory phthalazin-4-ylacetic acid deriv
文献作者:Brittain,D.R.; Wood,R.(AstraZeneca plc)
参考来源:EP 0002895; US 4251528
合成路线:This compound can be obtained by two different ways:1) By fluorination of 8,9-anhydroerythromycin A 6,9-hemiketal N-oxide (I) with trifluoromethyl hypofluorite (or perchloryl fluoride),followed by reduction of the corresponding N-oxide obtained.2) By biological synthesis,starting from (8S)-8-fluoroerythronolide A (II) in a culture broth of Streptomyces erythraeus ATCC 31772,a blocked mutant of an erythromycin-producing strain.
参考文献标题:Flurithromycin
文献作者:de Angelis,L.
参考来源:Drugs Fut 1987,12(3),214
合成路线:This compound can be obtained by two different ways:1) By fluorination of 8,9-anhydroerythromycin A 6,9-hemiketal N-oxide (I) with trifluoromethyl hypofluorite (or perchloryl fluoride),followed by reduction of the corresponding N-oxide obtained.2) By biological synthesis,starting from (8S)-8-fluoroerythronolide A (II) in a culture broth of Streptomyces erythraeus ATCC 31772,a blocked mutant of an erythromycin-producing strain.
参考文献标题:New fluorinated erythromycins obtained by mutasynt
文献作者:Toscano,L.; Fiorello,G.; Spagnoli,R.; Cappelletti,L.; Zanuso,G.
参考来源:J Antibiot 1983,361439
合成路线:This compound can be obtained by two different ways:1) By fluorination of 8,9-anhydroerythromycin A 6,9-hemiketal N-oxide (I) with trifluoromethyl hypofluorite (or perchloryl fluoride),followed by reduction of the corresponding N-oxide obtained.2) By biological synthesis,starting from (8S)-8-fluoroerythronolide A (II) in a culture broth of Streptomyces erythraeus ATCC 31772,a blocked mutant of an erythromycin-producing strain.
参考文献标题:Preparation of (8S)-8-fluoroerythronolide A and (8
文献作者:Toscano,L.; Fiorello,G.; Silingardi,S.; Inglesi,M.
参考来源:Tetrahedron Asymmetry 1984,112177
产品链接: CAS No. 82664-20-8››