合成路线:1,1,1,3,3,3-Hexafluoro-2-propyl methyl ether (I) is photochlorinated with Cl2 giving 1,1,1,3,3,3-hexafluoro-2-propylchloromethyl ether (II),which is then fluorinated with KF in tetrahydrothiophene-1,1-dioxide.
参考文献标题:Sevoflurane
文献作者:Sungurbey,K.; Castar,J.
参考来源:Drugs Fut 1976,1(6),307
合成路线:The synthesis of deuterated sevoflurane has been described:The methylation of 1,1,1,3,3,3-hexafluoroisopropanol (I) with deuterated dimethylsulfate by means of 10% aqueous NaOH yields the corresponding deuterated methyl ether (II),which is then fluorinated with BrF3.
参考文献标题:Synthesis of fluoro-dideutero-methyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (deuterated sevoflurane)
文献作者:Baker,M.T.; Chiang,C.-K.; Tinker,J.H.
参考来源:J Label Compd Radiopharm 1993,33(9),801
合成路线:A new method for the preparation of sevoflurane has been described: Reaction of 1,1,1,3,3,3-hexafluoro-2-propanol (I) with 1,3,5-trioxane (II) and AlCl3 gives the chloromethyl ether (III),which is then fluorinated with KF in hot polyethylene glycol (PEG-400).
参考文献标题:A safe and efficient process for the synthesis of the inhalation anesthetic sevoflurane
文献作者:Schure,R.M.; Behme,C.; Ramakrishma,K.; Bieniarz,C.
参考来源:Org Process Res Dev 2000,4(6),581
合成路线:1,1,1,3,3,3-Hexafluoro-2-propyl methyl ether (I) is photochlorinated with Cl2 giving 1,1,1,3,3,3-hexafluoro-2-propylchloromethyl ether (II),which is then fluorinated with KF in tetrahydrothiophene-1,1-dioxide.
参考文献标题:Halogenmethyl-1,3-polyhalogen-2-propyll鋞hen und Verfahren zu deren Herstellung sowie diese enthaltende An鋝thesie-Mittel
文献作者:Regan,B.M.; Longstreet,J.C.
参考来源:DE 1954268; FR 2021695; GB 1250928; NL 6916076
产品链接: CAS No. 28523-86-6››