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项目整合精选>>>Norfloxacin, MK-0366, AM-715, Norflo, Lexinor, Baccidal, Sebercim, Noroxin, Fulgram, Barazan
Norfloxacin, MK-0366, AM-715, Norflo, Lexinor, Baccidal, Sebercim, Noroxin, Fulgram, Barazan
氟哌酸 盐酸诺氟沙星 Chemical Name: 1-Ethyl-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
CAS No. 70458-96-7, 68077-27-0 (monoHCl)
项目整合开发状态: Launched-1984
项目研究机构: ISF (Originator), Istituto Biologico Chemioterapico ABC (Originator), Merck & Co. (Originator), Merck Sharp & Dohme (Originator), Kyorin (Not Determined), AstraZeneca (Licensee), Shire Pharmaceuticals (Licensee)
合成路线:By condensation of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) with piperazine (II) by heating at 170 C in water in a pressure tube.
📌 参考资料/链接：
参考文献标题:Piperazinyl derivs.of quinoline carboxylic acids
文献作者:Irikura,T.(Kyorin Pharmaceutical Co.,Ltd.)
参考来源:US 4146719
📄 详细内容
合成路线:By condensation of 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (I) with piperazine (II) by heating at 170 C in water in a pressure tube.
参考文献标题:AM-715
文献作者:Blancafort,P.; Sweetman,A.J.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(8),462
产品链接: CAS No. 70458-96-7›› 产品链接: CAS No.68077-27-0››