Flestolol sulfate, ACC-9089
氟司洛尔硫酸盐 氟司洛尔 Chemical Name: 2-Fluorobenzoic acid 3-(1,1-dimethyl-2-ureidoethylamino)-2-hydroxypropyl ester sulfate (1:1) salt
CAS No. 88844-73-9, 87721-62-8 (free base)
项目整合开发状态: Phase II
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The condensation in DMF of 1,1-dimethyl-2-[(aminocarbonyl)amino]ethylamine (III) [prepared from 1,2-diamino-2-methylpropane (I) and urea (II)] and 2,3-epoxypropyl o-fluorobenzoate (VI) [prepared from o-fluorobenzoyl chloride (VI) and glycidol (V) in diethyl ether using triethylamine as a proton scavenger],followed by salt formation using 98% sulfuric acid in ethanol yields ACC-9089.
📌 参考资料/链接：
参考文献标题:ACC-9089
文献作者:Day,B.W.; Pento,J.T.
参考来源:Drugs Fut 1985,10(6),447
📄 详细内容
合成路线:The condensation in DMF of 1,1-dimethyl-2-[(aminocarbonyl)amino]ethylamine (III) [prepared from 1,2-diamino-2-methylpropane (I) and urea (II)] and 2,3-epoxypropyl o-fluorobenzoate (VI) [prepared from o-fluorobenzoyl chloride (VI) and glycidol (V) in diethyl ether using triethylamine as a proton scavenger],followed by salt formation using 98% sulfuric acid in ethanol yields ACC-9089.
参考文献标题:[(Arylcarbonyl)oxy]propanolamines.1.Novel beta-blockers with ultrashort duration of action
文献作者:Kam,S.T.; Matier,W.L.; Mai,K.X.; Barcelon-Yang,C.; Borgman,R.J.; O'Donnel,J.P.; Sum,C.Y.; Anderson,W.G.; Gorczynski,R.J.; et al.
参考来源:J Med Chem 1984,27(8),1007
产品链接: CAS No. 88844-73-9›› 产品链接: CAS No.87721-62-8››