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项目整合精选>>>Flutamide, NK-601, NFBA, FTA, Sch-13521, Prostandril, Chimax, Odyne, Eulexine, Eulexin, Drogenil
Flutamide, NK-601, NFBA, FTA, Sch-13521, Prostandril, Chimax, Odyne, Eulexine, Eulexin, Drogenil
氟他胺Chemical Name: N-(Isopropylcarbonyl)-4-nitro-3-trifluoromethylaniline; N-Isobutyryl-4-nitro-3-trifluoromethylaniline; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
CAS No. 13311-84-7
项目整合开发状态: Launched-1983
项目研究机构: Schering-Plough (Originator), Chiron (Licensee), Nippon Kayaku (Licensee), Pliva (Licensee)
合成路线:By condensation of 4-nitro-3-trifluoromethylaniline (II) with isobutiryl (I) in pyridine.
📌 参考资料/链接：
参考文献标题:Flutamide
文献作者:Thorpe,P.; Castar,J.
参考来源:Drugs Fut 1976,1(3),108
📄 详细内容
合成路线:The synthesis of heptadeuterated flutamide has been reported: The reaction of deuterated isopropyl bromide (I) with Mg in THF gives the corresponding Grignard reagent (II),which is treated with CO2 yielding the deuterated isobutyric acid (III).The reaction of (III) with oxalyl chloride affords the expected acyl chloride (IV),which is finally condensed with 4-nitro-3-(trifluoromethyl)aniline (V).
参考文献标题:Synthesis of flutamide-d7 and its main metabolite-d6
文献作者:Passarella,D.; et al.
参考来源:J Label Compd Radiopharm 1999,42(3),275
合成路线:By condensation of 4-nitro-3-trifluoromethylaniline (II) with isobutiryl (I) in pyridine.
参考文献标题:Nouveaux anilides substitu閟 th閞apeutiquement actifs et leurs proc閐閟 de fabrication
文献作者:Neri,R.O.; et al.
参考来源:FR 2142803
合成路线:By condensation of 4-nitro-3-trifluoromethylaniline (II) with isobutiryl (I) in pyridine.
参考文献标题:Substituierte Anilide
文献作者:Neri,R.O.; et al.
参考来源:DE 2130450
产品链接: CAS No. 13311-84-7››