Gossypol

棉酚Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-diisopropyl-(2,2'-binaphthalene)-8,8'-dicarboxaldehyde; 2,2'-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-formylnaphthalene)
CAS No. 303-45-7
项目整合开发状态: Phase II
项目研究机构: Xian Lijun Pharmaceutical (Originator), Bioenvision (Licensee)
合成路线:The condensation of 3,4-dimethoxy-2-isopropylbenzaldehyde (I) with diethyl succinate (II) by means of NaH in refluxing benzene gives 2-(2-isopropyl-3,4-dimethoxybenzylidene)succinic acid monoethyl ester (III),which is cyclized by treatment with acetic anhydride and sodium acetate in refluxing acetic acid and hydrolyzed with NaOH in refluxing methanol yielding acid (IV).The reduction of (IV) with LiAlH4 in ether affords 3-hydroxymethyl-5-isopropyl-6,7-dimethoxy-1-naphthol (V),which is hydrogenated with H2 over Pd/C in methanol with some HCl giving 3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol (VI).Thermal dimerization of (VI) by heating at 215 C yields 2,2'-bis(3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol) (VII).

合成路线:Intermediate (VII) is methylated with dimethylsulfate and KOH in refluxing aqueous dioxane affording apogossypol hexamethyl ether (VIII) .The cleavage of the methoxy groups with BBr3 and aqueous NaOH yields apogossypol (IX),which by reaction with N,N'-diphenylformamidine (X) affords gossypol bis(N-phenylimine) (XI),which is finally hydrolyzed.
📌 参考资料/链接:
参考文献标题:Gossypol
文献作者:Leeson,P.
参考来源:Drugs Fut 1979,4(5),338

📄 详细内容


合成路线:The condensation of 3,4-dimethoxy-2-isopropylbenzaldehyde (I) with diethyl succinate (II) by means of NaH in refluxing benzene gives 2-(2-isopropyl-3,4-dimethoxybenzylidene)succinic acid monoethyl ester (III),which is cyclized by treatment with acetic anhydride and sodium acetate in refluxing acetic acid and hydrolyzed with NaOH in refluxing methanol yielding acid (IV).The reduction of (IV) with LiAlH4 in ether affords 3-hydroxymethyl-5-isopropyl-6,7-dimethoxy-1-naphthol (V),which is hydrogenated with H2 over Pd/C in methanol with some HCl giving 3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol (VI).Thermal dimerization of (VI) by heating at 215 C yields 2,2'-bis(3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol) (VII).

合成路线:Intermediate (VII) is methylated with dimethylsulfate and KOH in refluxing aqueous dioxane affording apogossypol hexamethyl ether (VIII) .The cleavage of the methoxy groups with BBr3 and aqueous NaOH yields apogossypol (IX),which by reaction with N,N'-diphenylformamidine (X) affords gossypol bis(N-phenylimine) (XI),which is finally hydrolyzed.

参考文献标题:
文献作者:El-Nockrashy
参考来源:J Am Oil Chem Soc 1963,40(1),14


合成路线:The condensation of 3,4-dimethoxy-2-isopropylbenzaldehyde (I) with diethyl succinate (II) by means of NaH in refluxing benzene gives 2-(2-isopropyl-3,4-dimethoxybenzylidene)succinic acid monoethyl ester (III),which is cyclized by treatment with acetic anhydride and sodium acetate in refluxing acetic acid and hydrolyzed with NaOH in refluxing methanol yielding acid (IV).The reduction of (IV) with LiAlH4 in ether affords 3-hydroxymethyl-5-isopropyl-6,7-dimethoxy-1-naphthol (V),which is hydrogenated with H2 over Pd/C in methanol with some HCl giving 3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol (VI).Thermal dimerization of (VI) by heating at 215 C yields 2,2'-bis(3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol) (VII).

合成路线:Intermediate (VII) is methylated with dimethylsulfate and KOH in refluxing aqueous dioxane affording apogossypol hexamethyl ether (VIII) .The cleavage of the methoxy groups with BBr3 and aqueous NaOH yields apogossypol (IX),which by reaction with N,N'-diphenylformamidine (X) affords gossypol bis(N-phenylimine) (XI),which is finally hydrolyzed.

参考文献标题:Studies in the naphtalene series.III.Synthesis of apogossypol hexamethyl ether
文献作者:Cashaw,J.L.; Edwards,J.D.Jr.
参考来源:J Am Chem Soc 1957,792283


合成路线:The condensation of 3,4-dimethoxy-2-isopropylbenzaldehyde (I) with diethyl succinate (II) by means of NaH in refluxing benzene gives 2-(2-isopropyl-3,4-dimethoxybenzylidene)succinic acid monoethyl ester (III),which is cyclized by treatment with acetic anhydride and sodium acetate in refluxing acetic acid and hydrolyzed with NaOH in refluxing methanol yielding acid (IV).The reduction of (IV) with LiAlH4 in ether affords 3-hydroxymethyl-5-isopropyl-6,7-dimethoxy-1-naphthol (V),which is hydrogenated with H2 over Pd/C in methanol with some HCl giving 3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol (VI).Thermal dimerization of (VI) by heating at 215 C yields 2,2'-bis(3-methyl-5-isopropyl-6,7-dimethoxy-1-naphthol) (VII).

合成路线:Intermediate (VII) is methylated with dimethylsulfate and KOH in refluxing aqueous dioxane affording apogossypol hexamethyl ether (VIII) .The cleavage of the methoxy groups with BBr3 and aqueous NaOH yields apogossypol (IX),which by reaction with N,N'-diphenylformamidine (X) affords gossypol bis(N-phenylimine) (XI),which is finally hydrolyzed.
参考文献标题:Total synthesis of gossypol
文献作者:Edwards,J.D.Jr.
参考来源:J Am Chem Soc 1958,803798


产品链接: CAS No. 303-45-7››