Tolciclate, K-9147
桥萘酯Chemical Name: N-Methyl-N-(3-methylphenyl)carbamothioic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
CAS No. 50838-36-3
项目整合开发状态: Not Determined
项目研究机构:
合成路线:Compound can be prepared in two different ways both starting from sodium 1,4-methano-1,2,3,4-tetrahydro-6-naphthoxide (I):1) The reaction of (I) with thiophosgene in chloroform gives O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)chlorothioformiate (II),n(20 C)(D) = 1.5930,which is then condensed with N-methyl-m-toluidine in the same solvent.2) The condensation of (I) with N-methyl-N-(m-tolyl)thiocarbamoyl chloride (III) in acetone.
📌 参考资料/链接：
参考文献标题:Tolciclate
文献作者:Castar,J.; de Angelis,L.
参考来源:Drugs Fut 1976,1(11),543
📄 详细内容
合成路线:Compound can be prepared in two different ways both starting from sodium 1,4-methano-1,2,3,4-tetrahydro-6-naphthoxide (I):1) The reaction of (I) with thiophosgene in chloroform gives O-(1,4-methano-1,2,3,4-tetrahydro-6-naphthyl)chlorothioformiate (II),n(20 C)(D) = 1.5930,which is then condensed with N-methyl-m-toluidine in the same solvent.2) The condensation of (I) with N-methyl-N-(m-tolyl)thiocarbamoyl chloride (III) in acetone.
参考文献标题:Tetrahydro-2-naphthyl ester derivatives of tinonocarbanilic acids
文献作者:Melloni,P.; et al.
参考来源:DE 2313845; FR 2181835; GB 1364407; JP 49005955; US 3855263
产品链接: CAS No. 50838-36-3››