Sunifiram, DM-235
桑尼非拉姆Chemical Name: 1-(4-Benzoylpiperazin-1-yl)propan-1-one; 1-Benzoyl-4-(1-oxopropyl)piperazine
CAS No. 314728-85-3
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Firenze (Originator)
合成路线:Acylation of N-benzylpiperazine (I) with propionyl chloride afforded amide (II).Hydrogenolysis of the N-benzyl protecting group of (II) over Pd/C then gave N-propionyl piperazine (III),which was finally condensed with benzoyl chloride to yield the title diamide.
📌 参考资料/链接：
参考文献标题:1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs
文献作者:Bellucci,C.; Ghelardini,C.; Dei,S.; Bartolini,A.; Galeotti,N.; Romanelli,M.N.; Gualtiere,F.; Manetti,D.; Scapecchi,S.; Teodori,E.
参考来源:16th Int Symp Med Chem (Sept 18 2000,Bologna) 2000,Abst PB-119
📄 详细内容
合成路线:Acylation of N-benzylpiperazine (I) with propionyl chloride afforded amide (II).Hydrogenolysis of the N-benzyl protecting group of (II) over Pd/C then gave N-propionyl piperazine (III),which was finally condensed with benzoyl chloride to yield the title diamide.
参考文献标题:Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity
文献作者:Mannetti,D.; Ghelardini,C.; Bartolini,A.; Dei,S.; Galeotti,N.; Gualtiere,F.; Romanelli,M.N.; Teodori,E.
参考来源:J Med Chem 2000,43(23),4499
产品链接: CAS No. 314728-85-3››