Salazodine, Salazopyridazin
柳氮定Chemical Name: 5-[[p-[(6-Methoxy-3-pyridazinyl)sulfamoyl]phenyl]azo]salicylic acid
CAS No. 22933-72-8
项目整合开发状态: Phase II
项目研究机构: Russian Academy of Medical Sciences (Originator)
合成路线:The antibacterial sulfonamide sulfapyridazine (I) or its sodium salt (II) is treated with sodium nitrite in the presence of hydrochloric acid to give the appropriate diazonium chloride (III).Coupling reaction with salicylic acid (IV) yields salazopyridazin.
📌 参考资料/链接：
参考文献标题:SALAZODINE < Rec INN; NFN >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(1),33
📄 详细内容
合成路线:The antibacterial sulfonamide sulfapyridazine (I) or its sodium salt (II) is treated with sodium nitrite in the presence of hydrochloric acid to give the appropriate diazonium chloride (III).Coupling reaction with salicylic acid (IV) yields salazopyridazin.
参考文献标题:
文献作者:B鰐linger,L.E.; M鰈lenberg
参考来源:Acta Med Scand 1959,165241
合成路线:The antibacterial sulfonamide sulfapyridazine (I) or its sodium salt (II) is treated with sodium nitrite in the presence of hydrochloric acid to give the appropriate diazonium chloride (III).Coupling reaction with salicylic acid (IV) yields salazopyridazin.
参考文献标题:
文献作者:Gortiskaya,T.V.; et al.(Ordzhonikadze All-Union Sci.Res,Chem.Pharm.Inst.)
参考来源:USSR 504766
产品链接: CAS No. 22933-72-8››