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Ranitidine Bismutrex, Ranitidine bismuth citrate, GR-122311-X, Tritec, Pylorid

枸橼酸铋雷尼替丁Chemical Name: N-[2-[5-(Dimethylaminomethyl)furan-2-ylmethylsulfanyl]ethyl]-N'-methyl-2-nitroethene-1,1-diamine 2-hydroxypropane-1,2,3-tricarboxylate bismuth(3+) complex (1:1:1); N-[2-[5-[(Dimethylamino)methyl]-2-furanylmethylsulfanyl]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine compound with 2-hydroxy-1,2,3-propanetricarboxylic acid bismuth(3+) salt(1:1:1); N-[2-[[5-[(Dimethylamino)methyl]furfuryl]sulfanyl]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine,compound with bismuth(3+) citrate (1:1)
CAS No. 128345-62-0, 139638-15-6 (deleted CAS)
项目整合开发状态: Launched-1995
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The reaction of 2-furan-methanol (I) with dimethylamine and formaldehyde gives 5-(dimethylaminomethyl)furan-2-methanol (II),which is condensed with 2-sulfanylethylamine (III) yielding 2-[5-(dimethylaminomethyl)furan-2-ylsulfanyl]ethylamine (IV).The condensation of (IV) with 1-(methylamino)-1-(methylsulfanyl)-2-nitroethylene (V),obtained from 1,1,-bis(methylsulfanyl)-2-nitroethylene (VI) and methylamine,in hot acetone,or by heating at 100-120 C affords N-[2-[5-(dimethylaminomethyl)furan-2-ylmethylsulfanyl]ethyl]- N'-methyl-2-nitroethylene-1,1-diamine (VII) ,which is finally complexed with bismuth (+3) citrate (VIII),obtained by reaction of NO3BiO with citric acid (IX) in hot water.
📌 参考资料/链接：
参考文献标题:Ranitidine derivs
文献作者:Clitherow,J.W.(Glaxo Wellcome plc)
参考来源:BE 1003254; CH 679582; GB 2220937; JP 1990117684; US 5008256

📄 详细内容


合成路线:The reaction of 2-furan-methanol (I) with dimethylamine and formaldehyde gives 5-(dimethylaminomethyl)furan-2-methanol (II),which is condensed with 2-sulfanylethylamine (III) yielding 2-[5-(dimethylaminomethyl)furan-2-ylsulfanyl]ethylamine (IV).The condensation of (IV) with 1-(methylamino)-1-(methylsulfanyl)-2-nitroethylene (V),obtained from 1,1,-bis(methylsulfanyl)-2-nitroethylene (VI) and methylamine,in hot acetone,or by heating at 100-120 C affords N-[2-[5-(dimethylaminomethyl)furan-2-ylmethylsulfanyl]ethyl]- N'-methyl-2-nitroethylene-1,1-diamine (VII) ,which is finally complexed with bismuth (+3) citrate (VIII),obtained by reaction of NO3BiO with citric acid (IX) in hot water.

参考文献标题:Aminoalkyl furan derivs
文献作者:Bradshaw,J.; Price,B.J.; Clitherow,J.W.
参考来源:GB 1565966


合成路线:The reaction of 2-furan-methanol (I) with dimethylamine and formaldehyde gives 5-(dimethylaminomethyl)furan-2-methanol (II),which is condensed with 2-sulfanylethylamine (III) yielding 2-[5-(dimethylaminomethyl)furan-2-ylsulfanyl]ethylamine (IV).The condensation of (IV) with 1-(methylamino)-1-(methylsulfanyl)-2-nitroethylene (V),obtained from 1,1,-bis(methylsulfanyl)-2-nitroethylene (VI) and methylamine,in hot acetone,or by heating at 100-120 C affords N-[2-[5-(dimethylaminomethyl)furan-2-ylmethylsulfanyl]ethyl]- N'-methyl-2-nitroethylene-1,1-diamine (VII) ,which is finally complexed with bismuth (+3) citrate (VIII),obtained by reaction of NO3BiO with citric acid (IX) in hot water.
参考文献标题:Ranitidine Bismuth Citrate
文献作者:Castar,J.; Rabasseda,X.; Mealy,N.
参考来源:Drugs Fut 1995,20(5),480


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