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Lemildipine, NB-818, NPK-1886

来米地平 来米地平 Chemical Name: (?-2-(Aminocarbonyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 5-methyl 3-(1-methylethyl) ester; (?-2-(Carbamoyloxymethyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl 5-methyl ester
CAS No. 125729-29-5, 94739-29-4 (undefined stereoch.)
项目整合开发状态: Pre-Registered
项目研究机构: Banyu (Originator), Kowa (Licensee)
合成路线:1) By cyclization of methyl 2-(2,3-dichlorobenzylidene)acetoacetate (I) with isopropyl 3-amino-4-(carbamoyloxy)crotonate (II).

合成路线:2) By cyclization of (I) with isopropyl 4-(carbamoyloxy)-2-butynoate (III) and ammonium acetate (IV).

合成路线:By cyclization of (II) with 2,3-dichlorobenzaldehyde (V) and methyl acetoacetate (VI).
📌 参考资料/链接：
参考文献标题:2-N-Substd.or unsubstd.-carbamoyloxy-alkyl-1,4-dihydropyridine-3,5-dicarboxylic acid symmetrical or asymmetrical diester deriv.and its preparation
文献作者:Migano,T.et al.(Banyu Pharmaceutical Co.,Ltd.)
参考来源:JP 1984152373

📄 详细内容


合成路线:By esterification of 3-isopropyl 5-methyl 4-(2,3-dichlorophenyl)-2-hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (VII) with chlorosulfonyl isocyanate.

参考文献标题:A novel method for producing carbamoyloxyalkyl-1,4-dihydropyridine deriv.
文献作者:Miyano,T.; Suzuki,K.(Banyu Pharmaceutical Co.,Ltd.)
参考来源:JP 1985139671


合成路线:1) By cyclization of methyl 2-(2,3-dichlorobenzylidene)acetoacetate (I) with isopropyl 3-amino-4-(carbamoyloxy)crotonate (II).

合成路线:2) By cyclization of (I) with isopropyl 4-(carbamoyloxy)-2-butynoate (III) and ammonium acetate (IV).

合成路线:By cyclization of (II) with 2,3-dichlorobenzaldehyde (V) and methyl acetoacetate (VI).

合成路线:By esterification of 3-isopropyl 5-methyl 4-(2,3-dichlorophenyl)-2-hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (VII) with chlorosulfonyl isocyanate.
参考文献标题:NB-818
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(4),331


产品链接: CAS No. 125729-29-5››

产品链接: CAS No.94739-29-4››
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