合成路线:The reaction of di(4-chlorophenyl)disulfide (I) with tetraisopropyl methylenediphosphonate (II) by means of NaH in hot DMF gives tetraisopropyl (4-chlorophenyl)thiomethylenediphosphonate (III),which is finally hydrolyzed with refluxing aqueous 6N HCl.
参考文献标题:SR-41319
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1985,10(6),482
合成路线:A synthesis for [benzene-U-14C]-tiludronate has been described:The chlorination of [U-14C]-acetanilide (I) with tetrabutylammonium iodotetrachloride gives the corresponding 4-chloro derivative (II) (along with some of the 2-chloro isomer).The hydrolysis of (II) with concentrated HCl at 60 C yields the chloroaniline (III),which is converted to the corresponding diazonium salt (IV) with NaNO2 and HCl.The reaction of (IV) with ferric thiocyanate affords the labeled 4-chlorophenylthiocyanate (V),which is condensed with the lithium salt of methylenebis(phosphonic acid)tetraisopropyl ester (VI) in THF to yield 4-chlorophenylsulfanylmethylenebis(phosphonic acid)tetraisopropyl ester (VII).Finally,this compound is hydrolyzed with concentrated HCl or aqueous NaOH.
参考文献标题:Synthesis of disodium [benzene-U-C-14]-(4-chlorophenylthio)methylenediphosphonate,[benzene-U-C-14]-tiludronate
文献作者:Ellames,G.J.; Burgos,A.
参考来源:J Label Compd Radiopharm 1995,36(11),1071
产品链接: CAS No. 149845-07-8›› 产品链接: CAS No.89987-06-4››