Temoporfin, KW-2345, EF9, mTHPC, Foscan

替莫卟吩Chemical Name: 5,10,15,20-Tetra(3-hydroxyphenyl)-2,3-dihydro-21H,23H-porphine; 3,3',3'',3'''-(7,8-Dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol; 7,8-Dihydro-5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin; meta-Tetrahydroxyphenylchlorin
CAS No. 122341-38-2
项目整合开发状态: Launched-2002
项目研究机构: biolitec (Proprietary), biolitec (Orphan Drug), Scotia (Originator), Kyowa Hakko (Licensee)
合成路线:Tetra(m-hydroxyphenyl)porphyrin (I) was reduced with diimide,generated in situ from tosyl hydrazide in the presence of K2CO3 and pyridine.The resulting mixture containing dihydro- and tetrahydroporphyrins was then reoxidized by means of o-chloranil to produce the desired dihydro compound.