Tenilsetam, CAS-997
替尼西坦Chemical Name: (?-3-(2-Thienyl)-2-piperazinone
CAS No. 86696-86-8
项目整合开发状态: Discontinued
项目研究机构: Aventis Pharma (Originator)
合成路线:The cyclization of ethyl 2-(2-thienyl)glyoxylate (I) with ethylenediamine (II) in refluxing ethanol gives 3-(2-thienyl)-1,2,5,6-tetrahydropyrazin-2-one (III),which is reduced with H2 over Raney Nickel (RaNi) in hot ethanol at 50 bar.
📌 参考资料/链接：
参考文献标题:Novel piperazinones,their preparation and use
文献作者:Beyerle,R.; Bender,H.; Schindler,U.; Nitz,R.-E.; Martorana,P.A.(Cassella AG)
参考来源:DE 3132882; US 4598079
📄 详细内容
合成路线:The cyclization of ethyl 2-(2-thienyl)glyoxylate (I) with ethylenediamine (II) in refluxing ethanol gives 3-(2-thienyl)-1,2,5,6-tetrahydropyrazin-2-one (III),which is reduced with H2 over Raney Nickel (RaNi) in hot ethanol at 50 bar.
参考文献标题:Substd.5,6-dihydro-2(1H)-pyrazinones
文献作者:Tilford,C.H.; Carr,A.A.Jr.; Kuhn,W.L.(Aventis Pharmaceuticals,Inc.)
参考来源:US 3056784
合成路线:The cyclization of ethyl 2-(2-thienyl)glyoxylate (I) with ethylenediamine (II) in refluxing ethanol gives 3-(2-thienyl)-1,2,5,6-tetrahydropyrazin-2-one (III),which is reduced with H2 over Raney Nickel (RaNi) in hot ethanol at 50 bar.
参考文献标题:Telnisetam
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1988,13(2),130
产品链接: CAS No. 86696-86-8››