Tilisolol hydrochloride, N-696, Daim, Selecal
替利洛尔 盐酸替利洛尔 Chemical Name: (?-4-[3-(tert-Butylamino)-2-hydroxypropoxy]-N-methylisocarbostyril monohydrochloride; (?-4-[3-(tert-Butylamino)-2-hydroxypropoxy]-2-methylisoquinolin-1(2H)-one monohydrochloride
CAS No. 85136-71-6 (free base), 62774-96-3 (undefined isomer)
项目整合开发状态: Launched-1992
项目研究机构: Nisshin Pharma (Originator), Toyama (Originator)
合成路线:The condensation of N-methyl-4-hydroxyisocarbostyril (I) with epichlorohydrin (II) by means of sodium methoxide in hot methanol gives 4-(2,3-epoxypropoxy)-N-methylisocarbostyril (III),which is then treated with tert-butylamine (IV) in methanol,and with HCl.
📌 参考资料/链接：
参考文献标题:Isocarbostyril derivatives
文献作者:Fukushima,H.; Suzuki,Y.(Nisshin Flour Milling Co.,Ltd.)
参考来源:DE 2631080; GB 1501149; JP 52012178
📄 详细内容
合成路线:The condensation of N-methyl-4-hydroxyisocarbostyril (I) with epichlorohydrin (II) by means of sodium methoxide in hot methanol gives 4-(2,3-epoxypropoxy)-N-methylisocarbostyril (III),which is then treated with tert-butylamine (IV) in methanol,and with HCl.
参考文献标题:N-696
文献作者:Serradell,M.N.; Blancafort,P.; Thorpe,P.J.; Castar,J.
参考来源:Drugs Fut 1982,7(12),889
产品链接: CAS No. 85136-71-6›› 产品链接: CAS No.62774-96-3››