Troxolamide, NAT

曲索胺Chemical Name: 3-[N-(2,3-Dihydroxy-1-(hydroxymethyl)propyl]carbamoyl]-2,2,5,5-tetramethylpyrrolidin-1-oxyl radical
CAS No. 97546-74-2
项目整合开发状态: Preclinical
项目研究机构: Schering AG (Originator)
合成路线:Reaction of 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (I) with 6-amino-2,2-dimethyl-1,3-dioxepan-5-ol (II) yields 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (5-hydroxy-2,2-dimethyl-1,3-dioxepan-6-yl)amide (III).Subsequent acidic hydrolysis gives NAT.
📌 参考资料/链接:
参考文献标题:Nitroxyl cpds.,and diagnostic media based thereon
文献作者:Gries,H.; Niedballa,U.; Weinmann,H.-J.(Schering AG)
参考来源:EP 0133674; JP 1985094960; US 4925652

📄 详细内容


合成路线:Reaction of 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (I) with 6-amino-2,2-dimethyl-1,3-dioxepan-5-ol (II) yields 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (5-hydroxy-2,2-dimethyl-1,3-dioxepan-6-yl)amide (III).Subsequent acidic hydrolysis gives NAT.

参考文献标题:Amino-dioxepane intermediates for the synthesis of
文献作者:Ranganathan,R.; Sovak,M.(University of California,San Diego)
参考来源:EP 0033426


合成路线:Reaction of 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (I) with 6-amino-2,2-dimethyl-1,3-dioxepan-5-ol (II) yields 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (5-hydroxy-2,2-dimethyl-1,3-dioxepan-6-yl)amide (III).Subsequent acidic hydrolysis gives NAT.
参考文献标题:Nat
文献作者:Gries,H.
参考来源:Drugs Fut 1988,13(3),230


产品链接: CAS No. 97546-74-2››