合成路线:The epoxidation of 17beta-hydroxy-4-androsteno[2,3-d]isoxazole (I) with peracetic acid in benzene acetic acid-sodium acetate gives 4alpha,5-epoxy-17beta-hydroxyandrostano[2,3-d]isoxazole (II),which is then isomerized by treatment with sodium methoxide in THF.
参考文献标题:Trilostane
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(8),494
合成路线:The epoxidation of 17beta-hydroxy-4-androsteno[2,3-d]isoxazole (I) with peracetic acid in benzene acetic acid-sodium acetate gives 4alpha,5-epoxy-17beta-hydroxyandrostano[2,3-d]isoxazole (II),which is then isomerized by treatment with sodium methoxide in THF.
参考文献标题:Steroidal heterocycles.XIII.4alpha,5-Epoxy-5alpha-androst-2-eno[2,3-d]isoxazoles and related compounds
文献作者:Neumann,H.C.; Potts,G.O.; Ryan,W.T.; Stonner,F.W.
参考来源:J Med Chem 1970,13(5),948-951
合成路线:The epoxidation of 17beta-hydroxy-4-androsteno[2,3-d]isoxazole (I) with peracetic acid in benzene acetic acid-sodium acetate gives 4alpha,5-epoxy-17beta-hydroxyandrostano[2,3-d]isoxazole (II),which is then isomerized by treatment with sodium methoxide in THF.
参考文献标题:2-Cyano steroids
文献作者:Clinton,R.O.; Manson,A.J.
参考来源:BE 0690024; DE 1593564; FR 63668M; NL 6616225; US 3296255
产品链接: CAS No. 13647-35-3››