Troxipide, KU-54, Aplace
曲昔派特Chemical Name: (?-3-(3,4,5-Trimethoxybenzamido)piperidine
CAS No. 30751-05-4
项目整合开发状态: Launched-1986
项目研究机构: Kyorin (Originator)
合成路线:The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III),which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.
📌 参考资料/链接：
参考文献标题:KU-54
文献作者:Blancafort,P.; Castar,J.; Dharma,A.P.; Serradell,M.N.
参考来源:Drugs Fut 1979,4(12),882
📄 详细内容
合成路线:The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III),which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.
参考文献标题:New antiulcer agents.1.Syntheses and biological activities of 1-acyl-2-,-3- and -4-substituted benzamidopiperidines
文献作者:Irikura,T.; Kasuga,K.
参考来源:J Med Chem 1971,14(4),357-361
合成路线:The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III),which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.
参考文献标题:Benzoylamino substituted 1-benzoylpiperidines
文献作者:Irikura,T.; et al.
参考来源:US 3647805
产品链接: CAS No. 30751-05-4››