Proquazone, Arthrex
普罗喹宗Chemical Name: 1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
CAS No. 22760-18-5
项目整合开发状态: Launched
项目研究机构: Novartis (Originator)
合成路线:The condensation of 2-amino-4-methylbenzophenone (I) with isopropyl iodide (II) by means of sodium carbonate gives 4-methyl-2-isopropylaminobenzophenone (III),which is the cyclized with urethane (A) under the catalytic action of ZnCl2 at 190 C.
📌 参考资料/链接：
参考文献标题:Proquazone
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1976,1(11),540
📄 详细内容
合成路线:The condensation of 2-amino-4-methylbenzophenone (I) with isopropyl iodide (II) by means of sodium carbonate gives 4-methyl-2-isopropylaminobenzophenone (III),which is the cyclized with urethane (A) under the catalytic action of ZnCl2 at 190 C.
参考文献标题:o-Isopropylaminobenzophenones
文献作者:Ott,H.; Denzer,M.
参考来源:DE 180550,1; FR 2002598; GB 1248428
产品链接: CAS No. 22760-18-5››