Premazepam, MDL-181, DL-181
普瑞西泮Chemical Name: 3,7-Dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-d]-1,4-diazepin-2(1H)-one
CAS No. 57435-86-6
项目整合开发状态: Biological Testing
项目研究机构: Lepetit (Originator)
合成路线:The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III),which is cyclized by reaction with hydrazine in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Premazepam
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(7),520
📄 详细内容
合成路线:The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III),which is cyclized by reaction with hydrazine in refluxing methanol.
参考文献标题:Pharmacologically active pyrrolodiazepines
文献作者:Fontanella,L.; Mariani,L.; Tarzia,G.
参考来源:DE 2511599; FR 2264546; GB 1433103; JP 50135094; US 4022766; US 4022766
合成路线:The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III),which is cyclized by reaction with hydrazine in refluxing methanol.
参考文献标题:3,7-Dihydro-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-ones.Synthesis and pharmaclogical properties
文献作者:Corsico,N.; Tarzia,G.; Fontanella,L.; Mariani,L.
参考来源:Eur J Med Chem - Chim Ther 1976,11(3),217-220
产品链接: CAS No. 57435-86-6››