Plafibride, ITA-104
普拉贝脲Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[N-(4-morpholinylmethyl)carbamoyl]propionamide
CAS No. 63394-05-8
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 2-(p-chlorophenoxy)isobutyric acid (I) with SOCl2 gives the corresponding acyl chloride (II) which is condensed with urea (III) in refluxing benzene yielding 2-(p-chlorophenoxy)isobutyrylurea (IV).The aminomethylation of (IV) with formaldehyde and morpholine (V) affords N-2-(p-chlorophenoxy)isobutyryl-N'-morpholinomethylurea which can be further purified through hydrochloride salt.
📌 参考资料/链接：
参考文献标题:
文献作者:Iniesta,J.
参考来源:DE 2716374; ES 447114
📄 详细内容
合成路线:The reaction of 2-(p-chlorophenoxy)isobutyric acid (I) with SOCl2 gives the corresponding acyl chloride (II) which is condensed with urea (III) in refluxing benzene yielding 2-(p-chlorophenoxy)isobutyrylurea (IV).The aminomethylation of (IV) with formaldehyde and morpholine (V) affords N-2-(p-chlorophenoxy)isobutyryl-N'-morpholinomethylurea which can be further purified through hydrochloride salt.
参考文献标题:Plafibride
文献作者:Ribalta,M.; Bruseghini,L.
参考来源:Drugs Fut 1979,4(1),42
产品链接: CAS No. 63394-05-8››