合成路线:This compound can be obtained by three different ways:1) The reaction of 3-nitrobenzaldehyde (I) with methyl acetoacetate (II) by means of m-toluidine in methanol gives methyl 2-(3-nitrobenzylidene)acetoacetate (III),which is then cyclized with 3-aminocrotonic acid 3-phenyl-2(E)-propenyl ester (IV) in refluxing isopropanol.2) By cyclization of methyl 3-aminocrotonate (V) with aldehyde (I) and acetoacetic acid 3-phenyl-2(E)-propenyl ester (VI) in refluxing isopropanol.3) By esterification of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (VII) with 3-phenyl-2(E)-propenyl alcohol (VIII),by means of dicyclohexylcarbodiimide (DCC) in pyridine.
参考文献标题:Process for preparing novel dihydropyridine derivs
文献作者:Nishitani,S.; Minamikawa,J.; Kano,M.; Otsubo,J.; Manabe,Y.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0173126
合成路线:This compound can be obtained by three different ways:1) The reaction of 3-nitrobenzaldehyde (I) with methyl acetoacetate (II) by means of m-toluidine in methanol gives methyl 2-(3-nitrobenzylidene)acetoacetate (III),which is then cyclized with 3-aminocrotonic acid 3-phenyl-2(E)-propenyl ester (IV) in refluxing isopropanol.2) By cyclization of methyl 3-aminocrotonate (V) with aldehyde (I) and acetoacetic acid 3-phenyl-2(E)-propenyl ester (VI) in refluxing isopropanol.3) By esterification of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (VII) with 3-phenyl-2(E)-propenyl alcohol (VIII),by means of dicyclohexylcarbodiimide (DCC) in pyridine.
参考文献标题:Dihydropyridine derivs
文献作者:Tamada,S.; Ei,K.; Teramoto,S.; Tanaka,T.; Nakagawa,T.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:JP 1986140567
合成路线:This compound can be obtained by three different ways:1) The reaction of 3-nitrobenzaldehyde (I) with methyl acetoacetate (II) by means of m-toluidine in methanol gives methyl 2-(3-nitrobenzylidene)acetoacetate (III),which is then cyclized with 3-aminocrotonic acid 3-phenyl-2(E)-propenyl ester (IV) in refluxing isopropanol.2) By cyclization of methyl 3-aminocrotonate (V) with aldehyde (I) and acetoacetic acid 3-phenyl-2(E)-propenyl ester (VI) in refluxing isopropanol.3) By esterification of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (VII) with 3-phenyl-2(E)-propenyl alcohol (VIII),by means of dicyclohexylcarbodiimide (DCC) in pyridine.
参考文献标题:OPC-13340
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1991,16(2),119
产品链接: CAS No. 99522-79-9›› 产品链接: CAS No.102106-08-1››