Prinoxodan, RGW-2938, WHR-2938
普啉索旦Chemical Name: 3-Methyl-6-(3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)-1,2,3,4-tetrahydroquinazolin-2-one
CAS No. 111786-07-3
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:The cyclization of 2-(methylaminomethyl)aniline (I) with 1,1'-carbonyldiimidazole (II) in refluxing THF gives 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (III),which is condensed with methyl succinyl chloride (IV) by means of anhydrous AlCl3 in refluxing carbon disulfide to yield 6-[3-(methoxycarbonyl)propionyl]-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (V).Finally,this compound is cyclocondensed with hydrazine in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Benzodiazinone-pyridazinone and hydroxy-pyrazolyl cpds.,cardiotonic compsns.including the same,and their uses
文献作者:Kuhla,D.E.; Campbell,H.F.; Studt,W.L.; Faith,W.C.; Molino,B.F.(Aventis Pharma SA)
参考来源:EP 0247177; JP 1988502030; US 4725686; WO 8703201
📄 详细内容
合成路线:The cyclization of 2-(methylaminomethyl)aniline (I) with 1,1'-carbonyldiimidazole (II) in refluxing THF gives 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (III),which is condensed with methyl succinyl chloride (IV) by means of anhydrous AlCl3 in refluxing carbon disulfide to yield 6-[3-(methoxycarbonyl)propionyl]-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one (V).Finally,this compound is cyclocondensed with hydrazine in refluxing ethanol.
参考文献标题:RGW-2938
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(2),132
产品链接: CAS No. 111786-07-3››