AN-9, Pivanex
新戊酰基氧基甲基丁酸酯Chemical Name: Butanoic acid pivaloyloxymethyl ester
CAS No. 122110-53-6
项目整合开发状态: Phase II
项目研究机构: Bar-Ilan University (Originator), Titan (Licensee)
合成路线:The title butyric acid prodrug was prepared by condensation of butyric acid (I) with chloromethyl pivalate (II) in the presence of Et3N in acetone.
📌 参考资料/链接：
参考文献标题:Biologically active carboxylic acid esters
文献作者:Nudelman,A.; Shaklai,M.; Rephaeli,A.(Bar-Ilan University)
参考来源:EP 0302349; JP 1998152436; JP 1998152454
📄 详细内容
合成路线:The title butyric acid prodrug was prepared by condensation of butyric acid (I) with chloromethyl pivalate (II) in the presence of Et3N in acetone.
参考文献标题:Novel anticancer prodrugs of butyric acid.2
文献作者:Nudelman,A.; Ruse,M.; Aviram,A.; Rabizadeh,E.; Shaklai,M.; Zimrah,Y.; Rephaeli,A.
参考来源:J Med Chem 1992,35(4),687
产品链接: CAS No. 122110-53-6››