合成路线:The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II),which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III).A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.
参考文献标题:Antifungal agent
文献作者:Seo,A.; Sugano,H.; Hasegawa,C.; Ikeda,K.; Munechica,Y.; Konoe,T.; Konaka,M.(Nihon Nohyaku Co.,Ltd.)
参考来源:JP 1987093227
合成路线:The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II),which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III).A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.
参考文献标题:Non-medicinal bactericidal agents and method for their preparation
文献作者:Seo,A.; Sugano,H.; Hasegawa,C.; Ikeda,K.; Nishimura,A.; Miyashiro,Y.(Nihon Nohyaku Co.,Ltd.)
参考来源:JP 1987093204
合成路线:The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II),which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III).A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.
参考文献标题:Ketene S,S-acetals
文献作者:Seo,A.; Sugano,H.; Hasegawa,C.; Miyashiro,Y.; Nishimura,A.; Ikeda,K.(Nihon Nohyaku Co.,Ltd.)
参考来源:JP 1985218387
合成路线:The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II),which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III).A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.
参考文献标题:A novel ketene S,S-acetal deriv.,a process for manufacturing thereof and a method for curing mycosis by administering it
文献作者:Seo,A.; Kanno,H.; Hasegawa,N.; Miyagi,Y.; Nishimura,A.; Konaka,S.; Ohmi,T.; Munechika,Y.; Uchida,M.; Ikeda,K.(Nihon Nohyaku Co.,Ltd.)
参考来源:EP 0218736
合成路线:The reaction of 2-(1-imidazolyl)acetonitrile (I) with CS2 and KOH in DMF gives the dithiolate (II),which is then cyclized with 1-(2-chlorophenyl)-1,2-di(methanesulfonyloxy)ethane (III).A column chromatography over silicagel allows the separation of the (E)- and (Z)-isomers.
参考文献标题:Lanoconazole
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1993,18(3),222
产品链接: CAS No. 101530-10-3››