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项目整合精选>>>Lacidipine, SN-305, GX-1048, GR-43659X, Viapres, Caldine, Motens, Lacipil, Lacirex
Lacidipine, SN-305, GX-1048, GR-43659X, Viapres, Caldine, Motens, Lacipil, Lacirex
拉西地平Chemical Name: (E)-4-[2-[2-(tert-Butoxycarbonyl)vinyl]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
CAS No. 103890-78-4
项目整合开发状态: Launched-1991
项目研究机构: GlaxoSmithKline (Originator), Boehringer Ingelheim (Licensee), Zambon (Licensee)
合成路线:The Wittig condensation of o-phthalaldehyde (I) with tert-butyl triphenylphosphoranylideneacetate (II) in methylene chloride gives tert-butyl 3-(2-formylphenyl)-2(E)-propenoate (III),which is then cyclized with ethyl 3-aminocrotonate (IV) in acetic acid.
📌 参考资料/链接：
参考文献标题:LACIDIPINE < Rec INN; BAN; USAN >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(4),317
📄 详细内容
合成路线:The Wittig condensation of o-phthalaldehyde (I) with tert-butyl triphenylphosphoranylideneacetate (II) in methylene chloride gives tert-butyl 3-(2-formylphenyl)-2(E)-propenoate (III),which is then cyclized with ethyl 3-aminocrotonate (IV) in acetic acid.
参考文献标题:1,4-dihydropyridines.
文献作者:Borthwick,A.D.; Pierccioli,D.; Micheli,D.; Semeraro,C.; Gaviraghi,G.(Glaxo SpA)
参考来源:ES 8703839; ES 8703839; US 4801599; US 5011848
产品链接: CAS No. 103890-78-4››