Lazabemide hydrochloride, Ro-19-6327/001, Tempium, Pakio
拉扎贝胺盐酸盐 拉扎贝胺 Chemical Name: N-(2-Aminoethyl)-5-chloropyridine-2-carboxamide hydrochloride
CAS No. 103878-83-7, 103878-84-8 (free base)
项目整合开发状态: Phase III
项目研究机构: Chugai (Originator), Roche (Originator)
合成路线:The reaction of 5-chloropyridine-2-carboxylic acid (I) with N-(2-aminoethyl)carbamic acid tert-butyl ester (II) by means of carbonyl-dimidazole (CDI) in refluxing THF gives N-[2-(tert-butoxycarbonylamino)ethyl]-5-chloropyridine-2-carboxamide (III),which is then hydrolyzed with trifluoroacetic acid in refluxing dichloromethane and treated with ethanolic HCl to obtain the hydrochloride.
📌 参考资料/链接：
参考文献标题:Ethylenediaminemonoamide derivs.,pharmaceutical compsns.containing them and use of these cpds.As antidepressants or antiparkinsonians
文献作者:Imhof,R.; Kyburz,E.(F.Hoffmann-La Roche AG)
参考来源:AU 8546636; CH 661043; CH 664755; DE 3530046; ES 8705407; ES 8800158; FR 2569694; JP 1986060657; JP 1995300417; US 4764522
📄 详细内容
合成路线:The reaction of 5-chloropyridine-2-carboxylic acid (I) with N-(2-aminoethyl)carbamic acid tert-butyl ester (II) by means of carbonyl-dimidazole (CDI) in refluxing THF gives N-[2-(tert-butoxycarbonylamino)ethyl]-5-chloropyridine-2-carboxamide (III),which is then hydrolyzed with trifluoroacetic acid in refluxing dichloromethane and treated with ethanolic HCl to obtain the hydrochloride.
参考文献标题:Lazabemide Hydrochloride
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1993,18(2),113
产品链接: CAS No. 103878-83-7›› 产品链接: CAS No.103878-84-8››