Tropisetron, ICS-205930, Novaban, Navoban
托烷司琼 盐酸托烷司琼 Chemical Name: 1H-Indole-3-carboxylic acid 3alpha-tropanyl ester; 1H-Indole-3-carboxylic acid endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
CAS No. 89565-68-4, 105826-92-4 (HCl)
项目整合开发状态: Launched-1992
项目研究机构: Novartis (Originator), Asta Medica (Licensee), Kyowa Hakko (Licensee)
合成路线:By condensation of indole 3-carbonyl chloride (I) with endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (II) by means of butyllithium in THF,or Na2CO3 in the same solvent.
📌 参考资料/链接：
参考文献标题:Pharmaceutically useful heterocyclic and carbocyclic acid esters and amides of alkylene bridged piperidines
文献作者:Donatsch,P.; Engel,G.; Stadler,P.; Richardson,B.P.; H黦i,B.(Novartis AG; Novartis Deutschland GmbH)
参考来源:CH 669792; CH 669954; DE 3322574; GB 2166726; GB 2166727; GB 2166728; US 4789673
📄 详细内容
合成路线:By condensation of indole 3-carbonyl chloride (I) with endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (II) by means of butyllithium in THF,or Na2CO3 in the same solvent.
参考文献标题:ICS-205930
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(2),106
产品链接: CAS No. 89565-68-4›› 产品链接: CAS No.105826-92-4››