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项目整合精选>>>Torsemide, Torasemide, BM-02015, JDL-464, AC-4464, GJ-1090, Sutril, Torocard, Torasemide N, Unat, Dilutol, Luprac, Torem, Torrem, Toradiur, Demadex, Sutril
Torsemide, Torasemide, BM-02015, JDL-464, AC-4464, GJ-1090, Sutril, Torocard, Torasemide N, Unat, Dilutol, Luprac, Torem, Torrem, Toradiur, Demadex, Sutril
托拉塞米Chemical Name: 1-Isopropyl-3-[4-(3-methylphenylamino)pyridin-3-ylsulfonyl]urea; N-(N-Isopropylcarbamoyl)-4-(3-methylphenylamino)pyridine-3-sulfonamide
CAS No. 56211-40-6
项目整合开发状态: Launched-1993
项目研究机构: Nycomed Pharma (Originator), Ferrer (Licensee), Malesci (Licensee), Roche (Licensee), Toyama (Licensee), Pliva (Generic)
合成路线:1) By condensation of 3-sulfonamido-4-(3-methylanilino)pyridine (I) with isopropylisocyanate (II) by means of triethylamine at 95 C.
合成路线:2) By condensation of m-toluidine (III) with 1-isopropyl-3-(4-chloro-3-pyridylsulfonyl)urea (IV) by means of Cu at 95 C.
📌 参考资料/链接：
参考文献标题:3-Loweralkylcarbamylsulfonamido-4-phenylaminopyridine-N-oxides,derivatives thereof and pharmaceutical compositions containing same
文献作者:Delarge,J.E.; Lapiere,C.L.; Georges,A.M.(A.Christiaens SA)
参考来源:BE 0827844; CH 609045; CH 610890; DD 121936; DD 126887; DE 2516025; FR 2267775; GB 1477664; JP 50142571; NL 7504521; US 4018929; US 4055650; ZA 7502243
📄 详细内容
合成路线:1) By condensation of 3-sulfonamido-4-(3-methylanilino)pyridine (I) with isopropylisocyanate (II) by means of triethylamine at 95 C.
合成路线:2) By condensation of m-toluidine (III) with 1-isopropyl-3-(4-chloro-3-pyridylsulfonyl)urea (IV) by means of Cu at 95 C.
参考文献标题:Torasemide
文献作者:Castar,J.; Blancafort,P.; Thorpe,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(3),223
产品链接: CAS No. 56211-40-6››