Zaltoprofen, ZC-102, CN-100, Peon, Soleton
扎托布洛芬 扎托洛芬 Chemical Name: (?-2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propionic acid; (?-alpha-Methyl-10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-acetic acid
CAS No. 89482-00-8, 74711-43-6 (undefined stereoch.)
项目整合开发状态: Launched-1993
项目研究机构: Nippon Chemiphar (Originator), Zeria (Licensee)
合成路线:The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II),which is then hydrolyzed with KOH in refluxing ethanol-water.
📌 参考资料/链接：
参考文献标题:Dibenzothiepine derivs.,process for their prepara
文献作者:Fujimoto,Y.; Yamabe,S.(Nippon Chemiphar Co.,Ltd.)
参考来源:DE 2941869; US 4247706
📄 详细内容
合成路线:The cyclization of 5-(1-cyanoethyl)-2-(phenylthio)phenylacetic acid (I) with polyphosphoric acid at 120 C gives 2-(10-oxo-10,11-dihydrodibenzo[b,flthiepin-2-yl)propionitrile (II),which is then hydrolyzed with KOH in refluxing ethanol-water.
参考文献标题:CN-100
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(4),302
产品链接: CAS No. 89482-00-8›› 产品链接: CAS No.74711-43-6››