Gallopamil hydrochloride, D-600, Algocor, Procorum
戈洛帕米Chemical Name: 5-[N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methylamino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile hydrochloride
CAS No. 16662-47-8 (free base)
项目整合开发状态: Launched-1983
项目研究机构: Abbott (Originator), Gr黱enthal (Originator), Ravizza (Licensee)
合成路线:Gallopamil is obtained by condensing 2-(3,4,5-trimethoxypheny)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-(2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) in the presence of bases.Compound (I) can be prepared by reaction of 3,4,5-trimethoxyphenylacetonitrile (III) with isopropyl chloride (IV) by means of NaNH2.Compound (II) is formed from 1-bromo-3-chloropropane (V) and N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (VI).
📌 参考资料/链接：
参考文献标题:Verfahren zur herstellung basisch substituerter phenylacetonitrile
文献作者:Dengel,F.(Knoll AG)
参考来源:DE 1154810; DE 1158083
📄 详细内容
合成路线:Gallopamil is obtained by condensing 2-(3,4,5-trimethoxypheny)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-(2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) in the presence of bases.Compound (I) can be prepared by reaction of 3,4,5-trimethoxyphenylacetonitrile (III) with isopropyl chloride (IV) by means of NaNH2.Compound (II) is formed from 1-bromo-3-chloropropane (V) and N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (VI).
参考文献标题:Gallopamil Hydrochloride
文献作者:Mannhold,R.
参考来源:Drugs Fut 1984,9(2),108
产品链接: CAS No. 16662-47-8››