Eniclobrate, Sgd-33374(hydrochloride)
恩尼贝特Chemical Name: 2-[4-(4-Chlorobenzyl)phenoxy]-2-methylbutyric acid pyridin-3-ylmethyl ester
CAS No. 60662-18-2, 57081-66-0 (hydrochloride)
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The condensation of 4-chloro-4?hydroxydiphenylmethane (I) with ethyl 2-bromo-2-methylbutyrate (II) by means of K2CO3 in refluxing xylene gives ethyl 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyrate (III),which by hydrolysis with KOH in refluxing ethanol is converted into the corresponding free acid (IV).The reaction of (IV) with refluxing SOCl2 affords 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyryl chloride (V),which is finally esterified with 3-hydroxymethylpyridine (VI) by means of pyridine in refluxing benzene.
📌 参考资料/链接：
参考文献标题:
文献作者:Thiele,K.; et al.
参考来源:BE 823904; CH 601169; CH 605557; CH 605642; DE 2461069; FR 2255891; GB 1497266; JP 75105621; NL 7416412; US 4115393; US 4153803
📄 详细内容
合成路线:The condensation of 4-chloro-4?hydroxydiphenylmethane (I) with ethyl 2-bromo-2-methylbutyrate (II) by means of K2CO3 in refluxing xylene gives ethyl 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyrate (III),which by hydrolysis with KOH in refluxing ethanol is converted into the corresponding free acid (IV).The reaction of (IV) with refluxing SOCl2 affords 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyryl chloride (V),which is finally esterified with 3-hydroxymethylpyridine (VI) by means of pyridine in refluxing benzene.
参考文献标题:Eniclobrate
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Hillier,K.
参考来源:Drugs Fut 1980,5(5),237
产品链接: CAS No. 60662-18-2›› 产品链接: CAS No.57081-66-0››