合成路线:The condensation of 2-methylpyridine (I) with 2-nitrobenzaldehyde (II) in acetic anhydride gives 2-(2-nitrostyryl)pyridine (III),which is quaternized with methyl iodide in refluxing acetone yielding 2-(2-nitrostyryl)-1-methylpyridinium iodide (IV) .The reduction of (IV) with H2 over PtO2 in ethanol affords 2-(2-aminophenethyl)-1-methylpiperidine (V),which is then acylated with 4-methoxybenzoyl chloride (A) in pyridine.
参考文献标题:MJ 9067
文献作者:Castar,J.
参考来源:Drugs Fut 1977,2(3),176
合成路线:The condensation of 2-methylpyridine (I) with 2-nitrobenzaldehyde (II) in acetic anhydride gives 2-(2-nitrostyryl)pyridine (III),which is quaternized with methyl iodide in refluxing acetone yielding 2-(2-nitrostyryl)-1-methylpyridinium iodide (IV) .The reduction of (IV) with H2 over PtO2 in ethanol affords 2-(2-aminophenethyl)-1-methylpiperidine (V),which is then acylated with 4-methoxybenzoyl chloride (A) in pyridine.
参考文献标题:Lysergic acid and quimidine analogs.2-(o-Acylaminophenethyl)piperidines
文献作者:Dykstra,S.J.; Minielli,J.L.; Lawson,J.E.; Ferguson,H.C.; Dungan,K.W.
参考来源:J Med Chem 1973,16(9),1015
合成路线:The condensation of 2-methylpyridine (I) with 2-nitrobenzaldehyde (II) in acetic anhydride gives 2-(2-nitrostyryl)pyridine (III),which is quaternized with methyl iodide in refluxing acetone yielding 2-(2-nitrostyryl)-1-methylpyridinium iodide (IV) .The reduction of (IV) with H2 over PtO2 in ethanol affords 2-(2-aminophenethyl)-1-methylpiperidine (V),which is then acylated with 4-methoxybenzoyl chloride (A) in pyridine.
参考文献标题:Substituted piperidines and a process for the preparation thereof
文献作者:Dykstra,S.J.; Minielli,J.L.
参考来源:BE 0779951; CA 961038; CH 578529; DE 2210154; FR 2128584; GB 1346261; NL 161443C; NL 7202614
产品链接: CAS No. 37612-13-8›› 产品链接: CAS No.66794-74-9››