Xibenolol hydrochloride((+)-enantiomer), D-32
希苯洛尔Chemical Name: (+)-1-tert-Butylamino-3-(2',3'-dimethylphenoxy)-2-propanol hydrochloride; (+)-1-tert-Butylamino-3-(2',3'-xylyloxy)-2-propanol hydrochloride
CAS No. 81584-06-7 (free base, racemic)
项目整合开发状态: Biological Testing
项目研究机构: Nikken Chemicals (Originator), Teikoku Hormone (Originator)
合成路线:It can be prepared in two different ways:1) The reaction of 1-chloro-2,3-propylene oxide (I) with tert-butylamine (II) in ether yields 1-chloro-3-tert-butylamino-2-propanol (III),which is condensed with 2,3-xylenol (IV) by means of KOH in ether-water.2) By heating a mixture of 1-tert-butyl-3-azetidinol (V) and 2,3-xylenol (IV) at 155 C with KOH.
📌 参考资料/链接：
参考文献标题:D-32
文献作者:Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1977,2(2),91
📄 详细内容
合成路线:It can be prepared in two different ways:1) The reaction of 1-chloro-2,3-propylene oxide (I) with tert-butylamine (II) in ether yields 1-chloro-3-tert-butylamino-2-propanol (III),which is condensed with 2,3-xylenol (IV) by means of KOH in ether-water.2) By heating a mixture of 1-tert-butyl-3-azetidinol (V) and 2,3-xylenol (IV) at 155 C with KOH.
参考文献标题:
文献作者:Suzuki,Y.; et al.
参考来源:JP 45029294
合成路线:It can be prepared in two different ways:1) The reaction of 1-chloro-2,3-propylene oxide (I) with tert-butylamine (II) in ether yields 1-chloro-3-tert-butylamino-2-propanol (III),which is condensed with 2,3-xylenol (IV) by means of KOH in ether-water.2) By heating a mixture of 1-tert-butyl-3-azetidinol (V) and 2,3-xylenol (IV) at 155 C with KOH.
参考文献标题:
文献作者:Tsukamoto,K.; et al.
参考来源:JP 46028534
产品链接: CAS No. 81584-06-7››