Butibufen, FF-106, Butilop醤, Mijal
布比布芬Chemical Name: alpha-Ethyl-4-(2-methylpropyl)benzeneacetic acid; 2-(4-Isobutylphenyl)butyric acid
CAS No. 55837-18-8
项目整合开发状态: Withdrawn
项目研究机构: Juste (Originator)
合成路线:Several methods for obtaining this compoud have been described:1) By treating the 4-isobutyl phenyl acetonitrile (I) with sodium amide and ethyl iodide,followed by the hydrolysis of the reaction product (II).2) The reaction of the nitrile (I) with sodium ethoxide and diethyl carbonate leads to the cyanoacetic ester (III),which is treated with ethyl iodide; thus (IV) being obtained,the hydrolysis and decarboxylation of (IV) leads to the final acid.3) The alkaline hydrolysis of the 4-isobutyl phenyl acetonitrile (I) leads to 4-isobutyl phenyl acetic acid (V).This product after treatment with Na in naphthalene and ethyl iodide (A) yields the required compound.
📌 参考资料/链接：
参考文献标题:Butibufen
文献作者:Aparicio,L.
参考来源:Drugs Fut 1977,2(3),156
📄 详细内容
合成路线:Several methods for obtaining this compoud have been described:1) By treating the 4-isobutyl phenyl acetonitrile (I) with sodium amide and ethyl iodide,followed by the hydrolysis of the reaction product (II).2) The reaction of the nitrile (I) with sodium ethoxide and diethyl carbonate leads to the cyanoacetic ester (III),which is treated with ethyl iodide; thus (IV) being obtained,the hydrolysis and decarboxylation of (IV) leads to the final acid.3) The alkaline hydrolysis of the 4-isobutyl phenyl acetonitrile (I) leads to 4-isobutyl phenyl acetic acid (V).This product after treatment with Na in naphthalene and ethyl iodide (A) yields the required compound.
参考文献标题:Procedimiento para la obtenci髇 del 醕ido 2-(4'-isobutifenil)but韗ico
文献作者:Aparicio,L.; et al.
参考来源:ES 427197; ES 435173; ES 435174
产品链接: CAS No. 55837-18-8››