Levosimendan, (-)-OR-1259, Simdax
左西孟旦 左西孟旦 Chemical Name: (R)-(-)-2-[4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenylhydrazono]propanedinitrile; (R)-(-)-2-[4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenylhydrazono]malonodinitrile; (R)-(-)-6-[4-(1,1-Dicyanomethylenehydrazino)phenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one
CAS No. 141505-33-1, 131741-08-7 (racemate)
项目整合开发状态: Launched-2000
项目研究机构: Orion Corp. (Originator), Abbott (Licensee)
合成路线:The optical resolution of 6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (I) with L-tartaric acid in isopropanol or D-tartaric acid in ethyl acetate gives the (R)-enantiomer (II),which is then condensed with malonodinitrile (III) by means of NaNO2 and HCl in cool water.
📌 参考资料/链接：
参考文献标题:Heterocyclic cpds.
文献作者:Haikala,H.O.; Nore,P.T.; Honkanen,E.J.; Pystynen,J.J.; L鰊nberg,K.K.; Luiro,A.M.; Pippuri,A.K.(Orion Corporation)
参考来源:EP 0383449; JP 1990288868; US 5019575; US 5122524; US 5185332
📄 详细内容
合成路线:The optical resolution of 6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (I) with L-tartaric acid in isopropanol or D-tartaric acid in ethyl acetate gives the (R)-enantiomer (II),which is then condensed with malonodinitrile (III) by means of NaNO2 and HCl in cool water.
参考文献标题:Pyridazine deriv.
文献作者:B鋍kstr鰉,R.J.; Haarala,J.V.; Honkanen,E.J.; Nore,P.T.; Wikberg,T.E.I.; Haikala,H.O.(Orion Corporation)
参考来源:GB 2251615; JP 1994504275; US 5424428; US 5512571; US 5569657; WO 9212135
合成路线:The optical resolution of 6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (I) with L-tartaric acid in isopropanol or D-tartaric acid in ethyl acetate gives the (R)-enantiomer (II),which is then condensed with malonodinitrile (III) by means of NaNO2 and HCl in cool water.
参考文献标题:Method for obtaining pure enantiomers of a pyridazinone deriv.
文献作者:Tanninen,V.P.; Timmerbacka,M.; Kaukonen,J.; Lehtonen,J.; Hypp鰈? R.; Muttonen,E.(Orion Corporation)
参考来源:WO 9735841
产品链接: CAS No. 141505-33-1›› 产品链接: CAS No.131741-08-7››