合成路线:The title compound was isolated by fractional crystallization of the diastereoisomeric mixture of calcium (6R,S)-folinate (Ia-b).This separation has been further improved with the addition of sodium EDTA.The separation of (6R,S) folinic acid has also been described by fractional crystallization of several diamine or polyamine salts of the diastereomeric mixture or by preparative chromatography.Alternatively,the fractional crystallization of 5,10-methenyl-(6R,S)-tetrahydrofolic acid (IIa-b) furnished isomer (III),which was subsequently hydrolyzed to the title compound at a pH of 5.5 to 6.5 in the presence of calcium chloride.
参考文献标题:Process for the separation of folinic acid
文献作者:Ulmann,M.; Conti,J.; M黮ler,H.R.; M黵del,G.
参考来源:EP 0367902; US 5010194
合成路线:The title compound was isolated by fractional crystallization of the diastereoisomeric mixture of calcium (6R,S)-folinate (Ia-b).This separation has been further improved with the addition of sodium EDTA.The separation of (6R,S) folinic acid has also been described by fractional crystallization of several diamine or polyamine salts of the diastereomeric mixture or by preparative chromatography.Alternatively,the fractional crystallization of 5,10-methenyl-(6R,S)-tetrahydrofolic acid (IIa-b) furnished isomer (III),which was subsequently hydrolyzed to the title compound at a pH of 5.5 to 6.5 in the presence of calcium chloride.
参考文献标题:A process for the preparation of substd.tetrahydrofolic derivs.in the 6(R,S)(-) forms and of their active 6(S)(-) N5 diastereoisomers in form of alkali and earth alkali metal salts
文献作者:Vecchi,G.
参考来源:EP 0537842
合成路线:The title compound was isolated by fractional crystallization of the diastereoisomeric mixture of calcium (6R,S)-folinate (Ia-b).This separation has been further improved with the addition of sodium EDTA.The separation of (6R,S) folinic acid has also been described by fractional crystallization of several diamine or polyamine salts of the diastereomeric mixture or by preparative chromatography.Alternatively,the fractional crystallization of 5,10-methenyl-(6R,S)-tetrahydrofolic acid (IIa-b) furnished isomer (III),which was subsequently hydrolyzed to the title compound at a pH of 5.5 to 6.5 in the presence of calcium chloride.
参考文献标题:A process for the separation of folinic acids
文献作者:Vecchi,G.
参考来源:WO 9315076
合成路线:The title compound was isolated by fractional crystallization of the diastereoisomeric mixture of calcium (6R,S)-folinate (Ia-b).This separation has been further improved with the addition of sodium EDTA.The separation of (6R,S) folinic acid has also been described by fractional crystallization of several diamine or polyamine salts of the diastereomeric mixture or by preparative chromatography.Alternatively,the fractional crystallization of 5,10-methenyl-(6R,S)-tetrahydrofolic acid (IIa-b) furnished isomer (III),which was subsequently hydrolyzed to the title compound at a pH of 5.5 to 6.5 in the presence of calcium chloride.
参考文献标题:Process for separating stereoisomers of folinic acid
文献作者:Felder,E.; Ripa,G.; Piva,R.(Bracco SpA)
参考来源:WO 9317022
合成路线:The title compound was isolated by fractional crystallization of the diastereoisomeric mixture of calcium (6R,S)-folinate (Ia-b).This separation has been further improved with the addition of sodium EDTA.The separation of (6R,S) folinic acid has also been described by fractional crystallization of several diamine or polyamine salts of the diastereomeric mixture or by preparative chromatography.Alternatively,the fractional crystallization of 5,10-methenyl-(6R,S)-tetrahydrofolic acid (IIa-b) furnished isomer (III),which was subsequently hydrolyzed to the title compound at a pH of 5.5 to 6.5 in the presence of calcium chloride.
参考文献标题:A process for the preparation and separation of diastereomeric salts of folinic acid
文献作者:Felder,E.; Ripa,G.; Distaso,C.(Bracco SpA; Dibra SpA)
参考来源:US 5710271; WO 9533749
合成路线:The title compound was isolated by fractional crystallization of the diastereoisomeric mixture of calcium (6R,S)-folinate (Ia-b).This separation has been further improved with the addition of sodium EDTA.The separation of (6R,S) folinic acid has also been described by fractional crystallization of several diamine or polyamine salts of the diastereomeric mixture or by preparative chromatography.Alternatively,the fractional crystallization of 5,10-methenyl-(6R,S)-tetrahydrofolic acid (IIa-b) furnished isomer (III),which was subsequently hydrolyzed to the title compound at a pH of 5.5 to 6.5 in the presence of calcium chloride.
参考文献标题:Method for the industrial preparation of (6S) folic acid derivs.by chromatographic separation
文献作者:Ambrosini,L.; Sala,B.
参考来源:EP 0627435
产品链接: CAS No. 80433-71-2››