Droxicam, E-3128, Drogelon, Ferpan, Ombolan
屈昔康Chemical Name: 5-Methyl-3-(2-pyridinyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
CAS No. 90101-16-9
项目整合开发状态: Withdrawn
项目研究机构: Esteve (Originator), Provesan (Originator), Pierre Fabre (Licensee)
合成路线:By condensation of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2 benzothiazine 1,1-dioxide (III) vvith 2 pyridylisocyanate (II) obtained in situ by decom position of 2-phenoxycarbonylaminopyridine (I).
合成路线:By chlorination of acid (I) and subsequent esterification with the aminoalcohol (II).
📌 参考资料/链接：
参考文献标题:A chlorobenzhydryl piperazine derivative
文献作者:Milani,C.; Carminati,G.M.; Sovera,A.(3M Pharmaceuticals)
参考来源:DE 2950378
📄 详细内容
合成路线:By condensation of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2 benzothiazine 1,1-dioxide (III) vvith 2 pyridylisocyanate (II) obtained in situ by decom position of 2-phenoxycarbonylaminopyridine (I).
参考文献标题:Droxicam
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(10),835
产品链接: CAS No. 90101-16-9››